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Symansis/CTRP-9, C1q-TNF-related protein-9/20 µg/9505

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¥4200.00
货号:9505
浏览量:127
品牌:Symansis
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CTRP-9, C1q-TNF-related protein-9

Catalog Number: 9505Availability: In StockSize:20 μgUniprot Nu :P0C862Species Reactivity :HumanHost :Human, HEK Cell Expessed
Symansis Direct Price USD $210.00
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CTRP-9DescriptionMSDS

The C1q TNF-related proteins (CTRPs) are a newly discovered highly conserved family of adiponectin paralogs, containing 15 members (CTRP1 to CTRP15). Although structurally related, the CTRP family members are functionally diverse. C1q-TNF-related protein-9 (CTRP9) is increasingly recognized as a promising cardioprotective adipocytokine, which regulates biological processes like vascular relaxation, proliferation, apoptosis, and inflammation. CTRP9 is the closest adiponectin paralog, and is predominantly expressed in adipose tissue. It also forms heterotrimers with adiponectin, and similarly to mouse adiponectin, reduces serum glucose. While many of CTRP9’s metabolic roles overlap those of adiponectin, CTRP9 is also being studied for its beneficial cardiovascular effects, especially related to atherosclerosis. For instance, in aortic vascular rings, CTRP9 caused significant vasorelaxation, and the vasoactive potency of CTRP9 exceeded that of adiponectin by 3-fold. This effect was endothelium-dependent and nitric oxide-mediated. Furthermore, CTRP9 modulates neointimal hyperplasia and vascular smooth muscle cell proliferation in vivo and in vitro. Moreover, a recent study found that CTRP9 attenuated adverse cardiac remodeling after ischemia-perfusion injury in mice. Thus, CTRP9 is likely to be involved in the regulation of vascular function, more specifically atherosclerosis, in both rodents and humans (Jung CH et al.,J Clin Endocrinol Metab. 2014 Dec;99(12):E2477-84).

Tags:CTRP-9,C19TA,C1QTNF9
Symansis的抑制剂阵列Easy50™阵列是连续稀释的药物阵列,已知它们专门靶向某些细胞信号分子。这些可直接应用于基于酶或细胞的测定,以达到跨越EC 50  和IC 50 的最终浓度 适合该药物的分子靶标。使用生成的信息,研究人员可以快速确定特定的细胞信号通路是否参与正在研究的生物过程。阵列的形式是一个96孔微孔板,包含12列,每列有一种或多种抑制剂,以及8行,每列包含该抑制剂的渐进稀释液,最后一行除外,该行留空作为阴性对照。对于每种抑制剂范围的稀释液从该抑制剂的IC的大约十分之一50 到一成百倍的IC 50