Fatty Acid Binding Protein/FABP4/aP2, Human, ELISA Kit

Fatty-acid binding protein 4 (FABP4), also termed adipocyte fatty-acid binding protein (A-FABP), or aP2, is a novel adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP-4 plays a key role in the link between obesity and various features of metabolic syndrome. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. Studies in human found FABP-4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop a metabolic syndrome and type 2 diabetes. Additionally, serum FABP-4 levels were associated with nonalcoholic fatty liver disease, carotid atherosclerosis and coronary artery diseaseThis Human FABP4 ELISA kit is designed for quantification of Human FABP4 in serum, plasma, and adipocyte extracts or cell culture media samples.The lowest level of FABP4 that can be detected by this assay is 0.39 ng/ml.The antibodies used in this assay are specific to human FABP4 and do not cross-react with mouse and rat FABP4, and other cytokine or hormone molecules.