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Stemrd/GDC-0941, PI3 kinase inhibitor/25 mg/G941-025

价格
¥3380.00
货号:G941-025
浏览量:127
品牌:Stemrd
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商品描述
SourceM.W.513.64CAS No.957054-30-7
Structural Info
FormulationPowder
ReconstitutionBefore reconstitution, werecommend a brief spin to drive down any material dislodged from the bottom ofthe tube. The compound is soluble inDMSO. Poorly Soluble in water. Dilution into protein-containing aqueousmedia is recommended.
StabilityThe powder is stable for atleast 2 year if stored at -20 °C.The dissolved compound is stable for at least 1 month at 4 °C, butshould be stored in aliquots at -20 °C for longer term. Protect from light.
PurityGreater than 99% as determined by LC/MS analysis.LC/MS and/or NMR data available upon request.
Biological Activity
Country of OriginUSA

Chemical Name: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidineGDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ,PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM,respectively. Administration of GDC-0941in animals displays significant inhibitory effect against established human cancerxenografts. It is currently in clinicaltrials.PI3Kinhibitors have been used for differentiation of pluripotent stem cells.Ref: Folkes AJ, et al. Theidentification of2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine(GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3kinase for the treatment of cancer. JMed Chem 51(18):5522-32, 2008 Touboul,et al. Generation of functional hepatocytes from human embryonic stem cellsunder chemically defined conditions that recapitulate liver development.Hepatology, 51: 1754–1765, 2010

Product Sheet
Stemrd的Y-27632,(1R,4r)-4-((R)-1-氨乙基)-N-(吡啶-4-基)环己烷-羧酰胺-2HCl,是一种Rho相关激酶(ROCK)抑制剂。Y27632已被证明可以防止凋亡,并提高解离的人类胚胎干(ES)细胞的存活率和克隆效率,而不会影响其多能性。