Source | M.W. | 311.36 | CAS No. | 1226056-71-8 | |
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Structural Info | |||||
Formulation | Powder | ||||
Reconstitution | Before reconstitution, we recommend a brief spin todrive down any material dislodged from the bottom of the tube. The compound is soluble in DMSO. | ||||
Stability | The powder is stable for at least 1 year if stored at-20 °C.The dissolved compound isstable for at least 1 month at 4 °C, but should be stored in aliquots at-20 °C for longer term. Protectfrom light. | ||||
Purity | Greater than 99% as determined by LC/MS analysis.LC/MS and/or NMR data available upon request. | ||||
Biological Activity | Tested active for culturing human iPS cells in serum-free medium on Matrigel coated plates. | ||||
Country of Origin | USA |
Thiazovivin,N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide, is a selectiveinhibitor of Rho-associated kinase (ROCK). It protects human ES cells from death in the absence of ECM byregulating E-cadherin mediated cell-cell interaction.Thiazovivin, in combination with inhibitorsof the TGF-beta receptor and the MEK kinases, improves reprogramming efficiencydramatically.Ref: Lin, T., et al. (2009) Achemical platform for improved induction of human iPSCs. Nature Methods. 6(11):805.