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商品描述
Anti-RND3 Antibody, Rabbit Polyclonal General Information
Product name
Anti-RND3 Antibody, Rabbit Polyclonal
Validated applications
WB
Species reactivity
Reacts with: Human Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)
Specificity
Human RND3
Immunogen
A synthetic peptide corresponding to the C-terminus of the Human RND3
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human RND3, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-RND3 Antibody, Rabbit Polyclonal Validated Applications
| Application | Dilution |
|---|---|
| WB | 1:500-1:1000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-RND3 Antibody, Rabbit Polyclonal Images
-HB08DE2625-WB.png)
Anti-RND3 rabbit polyclonal antibody at 1:500 dilution
Lane A: NCI-H460 Whole Cell Lysate
Lysates/proteins at 30 μg per lane.
Secondary
Goat Anti-Rabbit IgG H&L (Dylight800)at 1/10000 dilution.
Developed using the Odyssey technique.
Performed under reducing conditions.
Predicted band size:27 kDa
Observed band size:30 kDa
Anti-RND3 Antibody, Rabbit Polyclonal: Synonyms
Anti-ARHE Antibody; Anti-memB Antibody; Anti-Rho8 Antibody; Anti-RhoE Antibody
RND3 Background Information
Forced expression of RND3 inhibited Snail1 activity, which in turn blocked glioblastoma cell migration and invasion in vitro in cell culture and in vivo in GBM xenograft mice. Activation of Notch signaling contributes to glioblastoma multiform (GBM) tumorigenesis. The downregulation of RND3 is responsible for the enhancement of Notch activity that promotes glioblastoma genesis.
Full Name
Rho family GTPase 3
- Counteracting Genome Instability by p53-dependent MintosisAuthorLiang, J;Niu, Z;Yu, X;Zhang, B;Wang, M;Ruan, B;Qin, H;Year2020JournalbioRxivApplicationWBFoldedExpand
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