TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody General Information
TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody Validated Applications
Block: | In a functional ELISA which immobilized recombinant Human TNFR2 (Catalog# 10417-H08H) at 1 μg/mL (100 µL/well) in the plate, the Rabbit anti-Human TNFR2 Monoclonal Antibody (Catalog# 10417-R00N6) can block the binding of 2 μg/mL of biotinylated Human TNFα (Catalog# 10602-HNAE-B) to Human TNFR2 , the EC50 is 2.07 μg/mL . |
Neutralization: | The neutralization activity of TNFR2/TNFRSF1B Neutralizing Antibody is Measured by its ability to neutralize TNFR2/TNFRSF1B-mediated inhibition of cytotoxicity in the L‑929 mouse fibroblast cell line. The Neutralization titer (IC50) is typically 1-3 µg/mL in the presence of 1 μg/mL Recombinant Human TNFR2/TNFRSF1B, 0.25 ng/mL Recombinant Human TNFa, and 1 µg/mL actinomycin D. |
TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody Images
TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody: Synonyms
TNFR2/TNFRSF1B Background Information
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
- Neuroinflammation
- Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
- Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
- Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
- The TNF/TNFR2 signaling pathway is a key regulatory factor in endothelial progenitor cell immunosuppressive effectAuthorNaserian, S;Abdelgawad, ME;Afshar Bakshloo, M;Ha, G;Arouche, N;Cohen, JL;Salomon, BL;Uzan, G;Year2020JournalCell Commun. SignalApplicationco-culturePubMed ID: 32546175FoldedExpand
- TNFα priming through its interaction with TNFR2 enhances Endothelial Progenitor Cell immunosuppressive effect: a new hope for their widespread clinical applicationAuthorBARKESTANI, MN;SHAMDANI, S;BAKSHLOO, MA;Year2020JournalResearch SquareApplicationblockingFoldedExpand
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