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蚂蚁淘在线 / 品牌中心 / Sino Biological / Sino Biological/REG3B Protein, Mouse, Recombinant (His Tag)/1/51153-M08H
商品描述
REG3B Protein, Mouse, Recombinant (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mouse REG3B (NP_035166.1) (Met1-Gly175) was expressed with a C-terminal polyhistidine tag.
Accession#
NP_035166.1
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Glu 27
Molecule Mass
The recombinant mouse REG3B comprises 160 amino acids and has a predicted molecular mass of 18.1 kDa. The apparent molecular mass of the protein is approximately 19 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
REG3B Protein, Mouse, Recombinant (His Tag): Images
REG3B Protein, Mouse, Recombinant (His Tag): Synonyms
HIP Protein, Mouse; Pap Protein, Mouse; PAP1 Protein, Mouse; REG-III Protein, Mouse
REG3B Background Information
Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis.
- HIP/PAP protects against bleomycin-induced lung injury and inflammation and subsequent fibrosis in miceAuthorZheng, X;Li, Q;Tian, H;Li, H;Lv, Y;Wang, Y;He, L;Huo, Y;Hao, Z;Year2020JournalJ. Cell. Mol. Med.Applicationcell culturePubMed ID: 32352211FoldedExpand
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