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商品描述
Anti-CD38 Antibody, Mouse Monoclonal General Information
Product name
Anti-CD38 Antibody, Mouse Monoclonal
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human CD38
Immunogen
Recombinant Human CD38/ADPRC1 Protein (Catalog#10818-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD38/ADPRC1 (rh CD38/ADPRC1; Catalog#10818-H08H; NP_001766.2; Val43-Ile300). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #12
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-CD38 Antibody, Mouse Monoclonal Validated Applications
| Application | Dilution |
|---|---|
| FCM | 1:25-1:100 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-CD38 Antibody, Mouse Monoclonal Images
Flow cytometric analysis of Human CD38 expression on human whole blood lymphocytes. Cells were stained with purified anti-Human CD38, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
Anti-CD38 Antibody, Mouse Monoclonal: Synonyms
Anti-ADPRC 1 Antibody; Anti-ADPRC1 Antibody; Anti-T10 Antibody
CD38 Background Information
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.
Full Name
CD38 molecule
Research Areas
- Cancer Drug Targets
References
- Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
- Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
- Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
- Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cellsAuthorGao, Z;Tong, C;Wang, Y;Chen, D;Wu, Z;Han, W;Year2019JournalJ Genet GenomicsPubMed ID: 31466926FoldedExpand
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