BAPTAanditsderivativesarecalciumchelatorsthatarecommonlyusedtoformcalciumbufferswithwell-definedcalciumconcentrations.ByinjectingthechelatorsintocellsorbyincubatingcellswiththeAMesterformofthechelators,onecancontrolthecytosoliccalciumconcentration,animportantmeanstostudytherolesofcalcium.
KeyadvantagesofthesecalciumchelatorsincluderelativeinsensitivitytowardintracellularpHchangeandfastreleaseofcalcium.BiotiumoffersseveralBAPTAchelatorswithcalciumdissociationconstantscoveringtheBIOLOGicallysignificantrangefrom10-7to10-2M.
- Kd(noMg2):53uM
- MW:536
References
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