BAPTAanditsderivativesarecalciumchelatorsthatarecommonlyusedtoformcalciumbufferswithwell-definedcalciumconcentrations.ByinjectingthechelatorsintocellsorbyincubatingcellswiththeAMesterformofthechelators,onecancontrolthecytosoliccalciumconcentration,animportantmeanstostudytherolesofcalcium.KeyadvantagesofthesecalciumchelatorsincluderelativeinsensitivitytowardintracellularpHchangeandfastreleaseofcalcium.BiotiumoffersseveralBAPTAchelatorswithcalciumdissociationconstantscoveringtheBIOLOGicallysignificantrangefrom10-7to10-2M.
DimethylBAPTAAMesterisamembranepermeableformofDimethylBAPTAthatcanbeloadedintocellsbyincubation.DimethylBAPTAAMesteritselfdoesnotbindcalcium,butonceinsidethecellisconvertedintoDimethylBAPTAbycytoplasmicesterases.Seecatalogno.50008forinformationonDimethylBAPTA.
- Whitetooff-whitesolidsolubleinDMSO
- Storedesiccatedat-20°C
- C36H44N2O18
- MW:792.75
- [147504-94-7]
References
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