CNE-CPO (Cationic Nano Emulsion) Vaccine Adjuvant is an oil-in-water Cationic Nano Emulsion made of squalene droplets and cationic polymers in a continuous aqueous phase.

The cationic components that compose this nano-emulsion make it a genetic adjuvant that allows the association with plasmid DNA to form an efficient nanoparticle delivery system (NPD). NPD are non-viral gene delivery systems, self-assembled from cationic entities and negatively charged immunogen that function as vaccine carrier.

CNE-CPO Vaccine Adjuvant is biodegradable, an important advantage over alternative oils that have been used in emulsion adjuvants, like Freund’s adjuvant that contains mineral oil (paraffin oil) and has long term persistence in the organism. CNE induces local stimulation and recruitment of DCs and granulocytes, differentiation of monocytes into DCs and increased uptake of antigen by DCs. The emulsion acts more specifically on macrophages present at the site of injection. A local increase of chemokines released also influences the recruitment of immune cells from the blood to the site of vaccination, creating an amplification loop. This formulation enhances differentiation of monocytes towards a mature phenotype, thereby promoting migration of antigen-loaded cells to the draining lymph node.  

 

Sizes:

•  CNE-CPO is available in two quantities. #CNE1000 1mL; #CNE5000 5mL.

• Also available in bulk, please contact us : order@ozbiosciences.com

Storage: +4°C

Shipping conditions: Room Temperature

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OZ Biosciences的VaxOZ佐剂非常适合作为金标准参照物和任何免疫实验。也可以使用您自己的免疫刺激剂来定制它们。当前，佐剂仍然是提高常规和下一代疫苗效率的最重要策略。遗传佐剂是与特定抗原结合使用的免疫学试剂，可增强免疫反应。直接后果是与仅使用抗原相比，会产生更多的抗体和更长的免疫力，从而使疫苗所需的抗原剂量降至最低。特别是，基于DOTAP（1,2-油酰基--3-三甲基铵-丙烷）的阳离子脂质可诱导树突状细胞成熟，然后运输至引流淋巴结以激活抗原特异性T细胞。疫苗佐剂OZ生物科学VaxOZ佐剂是体内制造和质量控制的产品，仅用于研究目的。- AlumVax氢氧化物 / 磷酸盐，两个古典铝基佐剂- IFAVax， 不完全弗氏佐剂- CFAVax，完全弗氏佐剂- SqualVax，一个纳米油包水乳液-  CaLiVax-DOTAP， 对于脂质体介导的DNA或蛋白质疫苗基于阳离子脂质的组合物。