Lullaby is the ideal siRNA transfection reagent for gene silencing. Relying on the TEE-technology, it has been successfully tested on numerous cell lines, reaching up to 90% gene silencing with high reproducibility and a very low toxicity. RNA interference is a powerful technique to shut down genes expression in cells and organisms. This silencing effect constitutes a very helpful tool to study gene’s function and a promising approach for new therapeutic treatments. Short RNA duplexes (siRNA: small interfering RNA, shRNA: small hairpin RNA and dsRNA: double strand RNA) are extremely selective by interacting and inducing the degradation of their specific mRNA targets and thereby inhibit the resulting protein production. Lullaby® siRNA Transfection Reagent introduces the siRNA duplexes in a variety of cells with a very high efficiency leading to exceptional knockdown effects with low doses of siRNA.
"We initially collated a transfection reagent library of 26 reagents...By far, our preferred reagent is Lullaby from OZ Biosciences. We have used this reagent in over 20 cell lines and have found it essential in enabling siRNA screens in hard to tranfect cell lines..., with minimal toxicity"
Emma L. Shanks (2014) Strategic siRNA Screening Approaches to Target Cancer at the Cancer Research UK Beaston Institute, Combinatorial Chemistry & High Throughput Screening, 17:328-332
- Effective with very low doses of siRNA
- Minimized off-target effects
- Suitable for siRNA, shRNA, dsRNA, etc.
- Applicable to a broad range of cells
- Serum compatible & Non toxic
- Straightforward protocol
Lullaby transfection reagent:
Sizes:
- 500 µL: Up to 1000 assays
- 1000 µL: Up to 2000 assays
- 3 x 1000 µL: Up to 6000 assays
Storage: + 4°C
Shipping conditions: Room temperature
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OZ Biosciences的VaxOZ佐剂非常适合作为金标准参照物和任何免疫实验。也可以使用您自己的免疫刺激剂来定制它们。当前，佐剂仍然是提高常规和下一代疫苗效率的最重要策略。遗传佐剂是与特定抗原结合使用的免疫学试剂，可增强免疫反应。直接后果是与仅使用抗原相比，会产生更多的抗体和更长的免疫力，从而使疫苗所需的抗原剂量降至最低。特别是，基于DOTAP（1,2-油酰基--3-三甲基铵-丙烷）的阳离子脂质可诱导树突状细胞成熟，然后运输至引流淋巴结以激活抗原特异性T细胞。疫苗佐剂OZ生物科学VaxOZ佐剂是体内制造和质量控制的产品，仅用于研究目的。- AlumVax氢氧化物 / 磷酸盐，两个古典铝基佐剂- IFAVax， 不完全弗氏佐剂- CFAVax，完全弗氏佐剂- SqualVax，一个纳米油包水乳液- CaLiVax-DOTAP， 对于脂质体介导的DNA或蛋白质疫苗基于阳离子脂质的组合物。
