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4000-520-616 / 18915418616
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0512-67156496
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商品描述
BIOLOGICAL INFORMATION
DescriptionA-779 is a potent and selective Ang (1-7) antagonist. A-779 antagonizes several actions of Ang (1-7), including A-779"s antidiurectic effect and the changes in MAP produced by Ang (1-7) microinjection into the dorsomedial or ventrolateral medulla.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10687
CAS No.159432-28-7
NameA-779
Chemical NameA-779
Purity≥98%
SynonymsN/A
FormulaC39H60N12O11
Molecular Weight873
One Letter CodeDRVYIH{D-Ala}
Three Letter CodeASP-ARG-VAL-TYR-ILE-HIS-d-ALA
SMILESCCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)NC(C)C(=O)O)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
InChI KeyGZSZZUXDAPDPOR-NGIFJXEWSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingIce Pack
Stability≥ 2 years
REFERENCES & CITATIONS
1.Xue Het al. Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Regul Pept 177:12-20 (2012). Read more (PubMed: 22561449)
2.Bruce et al (2015) Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol.
3.Becker et al (2005) Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 1040 121 PMID: 15804433
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
