品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
BIOLOGICAL INFORMATION
DescriptionMotilin is a 22-amino-acid peptide secreted by endocrinocytes in the mucosa of the proximal small intestine. Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. Motilin is an intestinal peptide that stimulates contraction of gut smooth muscle. The motilin receptor has not been cloned yet, but motilin-receptor agonists appear to be potent prokinetic agents for the treatment of dysmotility disorders. The nucleic classic sequence for human motilin shows seven differences between it and the cDNA coding for pig motilin, but the amino acid sequence deduced from both sequences is identical.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10578
CAS No.52906-92-0
NameMotilin, human, porcine
Chemical NameMotilin,-human,-porcine
Purity≥98%
SynonymsN/A
FormulaC120H188N34O35S
Molecular Weight2699.05
One Letter CodeFVPIFTYGELQRMQEKERNKGQ
Three Letter CodePHE-VAL-PRO-ILE-PHE-THR-TYR-GLY-GLU-LEU-GLN-ARG-MET-GLN-GLU-LYS-GLU-ARG-ASN-LYS-GLY-GLN
SMILESCCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCSC)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)N)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C3CCCN3C(=O)C(C(C)C)NC(=O)C(CC4=CC=CC=C4)N
InChI KeyLVRVABPNVHYXRT-BQWXUCBYSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingIce Pack
Stability≥ 2 years
REFERENCES & CITATIONS
1.Broad and Sanger (2013) The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin. Br J Pharmacol 168 1859 PMID: 23190027
2.Matsuura B, et al. Differential Contributions of Motilin Receptor Extracellular Domains for Peptide and Non-peptidyl Agonist Binding and Activity. J. Biol. Chem. May 2006; 281(18): 12390-12396.
3.Koenig JB, et al. Effect of intraluminal distension or ischemic strangulation obstruction of the equine jejunum on jejunal motilin receptors and binding of erythromycin lactobionate. Am. J. Vet. Res. May 2006; 67(5): 815-820.
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
