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商品描述
BIOLOGICAL INFORMATION
DescriptionThis peptide sequence is found in residues 45 to 54 of Metastin (also referred to as Kisspeptin-10). This peptide increases plasma concentrations of GH (Growth Hormone) and LH (Luteinizing Hormone) in prepubertal dairy heifers. This peptide is the minimal sequence needed to activate GPR54 signaling, which may function in negatively regulating CXCR4s role in programming tumor metastasis. Specifically, Kisspeptin-10 inhibits signaling and chemotaxis induced by SDF-1.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10095
CAS No.374675-21-5
NameKisspeptin - 10 (Kp - 10), Metastin (45 - 54)
Chemical NameKisspeptin---10-(Kp---10),-Metastin-(45---54)
Purity≥98%
SynonymsN/A
FormulaC63H83N17O14
Molecular Weight1302.5
One Letter CodeYNWNSFGLRF-NH2
Three Letter CodeH-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
SMILESCC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)C(CO)NC(=O)C(CC(=O)N)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC(=O)N)NC(=O)C(CC5=CC=C(C=C5)O)N
InChI Key RITKWYDZSSQNJI-INXYWQKQSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingBlue Ice
Stability≥ 2 years
REFERENCES & CITATIONS
1.Constantin and Wray (2016) Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons. Endocrinology 157 3197 PMID: 27359210
2.Schwetz et al (2014) Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10. PLoS One 9 e113020 PMID: 25401335
3.Ji et al (2014) Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer. Autophagy 14 723 PMID: 25260785
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
