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商品描述
BIOLOGICAL INFORMATION
DescriptionThis acetylated peptide is amino acids 2 to 28 N-terminus fragment of Annexin 1 (ANXA1). ANXA1, previously referred to as lipocortin 1 or LC1, is a member of the annexin superfamily that has potent leukocyte antimigratory activity. This fragment, as well as the full-length ANXA1, may significantly reduce polymorphonuclear leukocyte (PMN) influx in mice. ANXA1 and ANXA1 mimetics, such as Ac (2-12), inhibit recruitment of neutrophils in acute and chronic inflammation. This peptide is able to inhibit neutrophil extravasation.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10032
CAS No.151988-33-9
NameAnnexin 1 (ANXA - 1, Ac 2 - 26)
Chemical NameAnnexin-1-(ANXA---1,-Ac-2---26)
Purity≥98%
SynonymsAnnexin-1 (2-26) (human)； Lipocortin-1 (2-26)； Calpactin II (1-25) (dephosphorylated) (human)； Ac2-26
FormulaC141H210N32O44S
Molecular Weight3041.4
One Letter CodeAc-AMVSEFLKQAWIENEEQEYVVQTVK
Three Letter CodeAc-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Val-Gln-Thr-Val-Lys-OH
SMILESN/A
InChI KeyN/A
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
Stability≥ 2 years
REFERENCES & CITATIONS
1.Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response.
2.Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice.
3.Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils.
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
