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商品描述
RapamycinPDF
Catalog Number:
E1B1842Amount:
0.1mgPHYSICAL APPEARANCE: Off-white or yellow solidMOLECULAR FORMULA: C51H79NO13
Molecular Weight:
914.2Purity:
98% (TLC: 10% MeOH/Methylene chloride; Rf = 0.51)Storage/Stability:
Store solutions at -20°C for up to 1 year.Recommended Dilutions:
Binds to and inhibits the FK506 binding protein (FKBP) proline rotamase. Rapamycin is bound simultaneously by FKBP12 and FRAP (FKBP12-Rapamycin-Associated-Protein). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 to S phase. Rapamycin selectively blocks signaling leading to the activation of p70/85 S6 kinase.References:
1. J.Y.Chang et al. Trends Pharmacol.Sci. 1991 12 2182. J.Choi et al. Science 1996 273 1833. D.M.Sabatini et al. J.Biol.Chem. 1995 270 208754. E.J.Brown et al. Nature 1995 377 4415. J.E.Kay et al. Immunology 1991 72 5446. W.G.Morice et al. J.Biol.Chem. 1993 268 37347. J.Heitman et al. Science 1991 253 9058. D.J.Price et al. Science 1992 257 9739. D.C.Fingar et al. J.Biol.Chem. 1993 268 300510. J.Chung et al. Cell 1992 69 1227The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.Price:
60$Form of Antibody:
RapamycinCAS NO: 53123-88-9
