Diatheva蚂蚁淘在线

Description

Cyclophilins belong to the superfamily of immunophilins, highly conserved cytoplasmic proteins which share the PPI enzymatic activity and the ability to bind immunosuppressive drugs. CypA binds to and mediates the effect of Cyclosporin A; the CsA/CypA complex selectively binds and inactivates the serine/theronine phosphatase calcineurin leading to disruption of T-cells activating cascade. CsA binding occurs at the active site of the protein thus inhibiting its enzymatic activity. CypA has been demonstrated to be involved in several steps of viral infections such as those mediated by HIV, HBV and HCV.Cyclophilin A (CypA, 18 kDa) is the first peptidyl-prolil cis-trans isomerase (PPIase) to be discovered; PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins.

Additional information

Size	500 µg
Application	Clinical diagnostics\| Life Sciences
Product type	Reagents for research
Reagent type	Recombinant protein
Category	Cyclophilins

Technical information

Accession number	GenBank NM_021130.3
Organism	Homo sapiens peptidylprolyl isomerase A (cyclophilin A) (PPIA), mRNA
Size	500 µg
Expression system	E.coli
Tag	HIS tagged
Purity	>99%
Form	Liquid, 20mM Tris pH 8.0, 20mM NaCl, 0.5mM DTT, 10%(v/v) glycerol.
Tested application	SDS-PAGE/WB
Shipping/storage conditions	Shipped at -20°C. The protein is stable for 12 months if stored at -80°C. Avoid repeated freeze/thaw cycles.
Usage	For Laboratory Research Use Only

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Diatheva多病原体富集培养基500克在分离程序之前，可以使用多病原体富集培养基肉汤富集食品样品中的沙门氏菌，单核细胞增生李斯特菌和大肠杆菌O157。沙门氏菌，单核细胞增生李斯特氏菌和大肠杆菌O157被公认为是主要的食源性病原体，因为它们继续与诸如乳制品之类的高度受欢迎的食品相关联。最重要的是，这些病原体具有很高的流行率和死亡率，并参与了最近的几次暴发（Lynch等，2006）。多病原体富集培养基可提供营养物质和稳定的pH条件，以提高单核细胞增生李斯特菌沙门氏菌的回收率。和大肠杆菌O157细胞。