Diatheva蚂蚁淘在线

Description

The HIV-1 regulatory protein Tat is considered an attractive target for the development of a multicomponent vaccine against HIV-1 infection. This protein is considered an attractive target for the development of a multicomponent vaccine against HIV-1 infection. The protein is well conserved among isolates and thus may be less susceptible to mutation leading to the production of escape virus variants. Tat is produced early after infection and it’s essential for virus replication and infectivity. Tat protein is also immunogenic and antibody against Tat have been correlated with delayed disease progression and may exert protective effects inhibiting HIV-1 replication. Moreover, Tat is efficiently taken up by monocyte-derived dentritic cells, promoting their maturation. Finally, murine vaccination wwith a biologically active Tat protein has been shown to be safe and immunogenic.

Additional information

Size	200 µL
Application	Clinical diagnostics\| Life Sciences
Product type	Reagents for research
Reagent type	Antibody
Category	HIV
Subcategory	Polyclonal Anti Tat antibody
Antibody type	Primary antibody
Immunogen	Recombinant purified Tat protein (HIV-1 Clade B) expressed in E.coli

Technical information

Size	200 µL
Purity	Purified by Protein A affinity Chromatography
Form	Liquid. Supplied in 100mM sodium citrate, 50mM Tris and 0.05% v/v glycerol. Neutral pH.
Shipping/storage conditions	Shipped at 2-8°C. When stored at +4°C the antibody is stable for 18 months. For extended storage up to 24 months, the solution may be frozen at -20°C in working aliquots. Avoid repested freezing and thawing cycles.
Usage	For Laboratory Research Use Only
Source	Rabbit
Specificity	Tat protein Clade A and B, GST-Tat fusion protein, Tat-Cys22 mutated in the trans activation domain and various Tat peptides
React with	Tat from HIV-1
Recommended dilutions	Recommended starting dilutions can vary lot-to-lot. Consult the suggested starting dilutions on the top of the page for lot specific values.

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Datasheet

References

DNA Vectors Generating Engineered Exosomes Potential CTL Vaccine Candidates Against AIDS, Hepatitis B, and Tumors	PUBMED ID: 30167966
Trans-dissemination of exosomes from HIV-1-infected cells fosters both HIV-1 trans-infection in resting CD4+ T lymphocytes and reactivation of the HIV-1 reservoir	PUBMED ID: 28474225
The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes	PUBMED ID: 28474333

Related products

Recombinant TAT Clade B BIOTIN HIV-1 TAT Recombinant Tat Clade B Biotein conjugated, isproduced in E.coli and conjugated with NHS Biotin.	REP0004
Recombinant TAT Clade B HIV-1 TAT Recombinant- produced in E.coli is a single, non-glycosylated, polypeptidic chain containing 86 amino acids encoded by two exons and having a molecular mass of 14kDa.	REP0002b
Recombinant TAT Cys22 HIV-1 regulatory Tat protein plays an essential role in viral replication and infectivity. In addition, during acute infection, Tat is released extracellularly by infected cells and is taken up by neighbouring cells where it transactivates viral replication and increases virus infectivity. The Tat cys22 protein of HIV-1 is a molecule of 86 aminoacids mutated in the trans activation domain.	REP0033
Recombinant TAT Clade D Recombinant (HIV-1) Tat clade D produced in E. coli. Productive HIV-1 replication is absolutely dependent upon the viral tat protein. In Uganda Clades A and D are responsible for approximately 95% of HIV-1 infections. The HIV-1 tat protein Clade A is a molecule of 86 aminoacids encoded by two exons and having a molecular mass of 18 kDa in SDS-PAGE.	REP0045
Recombinant TAT Clade B C27A-C31A Mutant Recombinant HIV-1 TAT Clade B C31A-C34A isproduced in E.coli and is mutate in the cystein-rich region. It Is a single, non-glycosylated, polypeptidic chain containing 86 amino acids encoded by two exons.	REP0061
Recombinant TAT Clade B C31A-C34A Mutant Recombinant HIV-1 TAT Clade B C31A-C34A isproduced in E.coli and is mutate in the cystein-rich region. It Is a single, non-glycosylated, polypeptidic chain containing 86 amino acids encoded by two exons.	REP0062
Recombinant TAT CRF02_AG Recombinant (HIV-1) CRF02_AG Tat produced in E.coli. The HIV-1 CFR02_AG Tat proteinis a molecule of 101 aminoacids encoded by two exons and having a molecular mass of 20.1kDa in SDS-PAGE.	REP0059
Rabbit Anti HIV-1 Tat Biotin conjugated The rabbit polyclonal Anti HIV-1 Tat antibody Biotin conjugated is a useful tool for detecting Tat transactivating regulatory protein. Theconjugation garantees an improvement on the specificsignal and the best signal on semidirect immunologicalmethods	ANT0003
Rabbit Anti HIV-I Tat FITC conjugated The rabbit polyclonal Anti HIV-1 Tat antibody FITC conjugated is a useful tool for detecting Tat transactivating regulatory protein. The florophore conjugation garantees an improvement on the specificsignal and the best signal on fluorescence methodologies	ANT0005
Rabbit Anti HIV-I Tat affinity purified The rabbit polyclonal Anti HIV-1 Tat antibody affinity purified is a useful tool for detecting Tat transactivating regulatory protein. The affinity purification protocol garantees an improvement on the specificsignal	ANT0041
Recombinant TAT Clade A Recombinant (HIV-1) Tat clade A produced in E. coli. Productive HIV-1 replication is absolutely dependent upon the viral tat protein. In Uganda Clades A and D are responsible for approximately 95% of HIV-1 infections. The HIV-1 tat protein Clade A is a molecule of 86 aminoacids encoded by two exons and having a molecular mass of 20.1 kDa in SDS-PAGE	REP0043

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Diatheva多病原体富集培养基500克在分离程序之前，可以使用多病原体富集培养基肉汤富集食品样品中的沙门氏菌，单核细胞增生李斯特菌和大肠杆菌O157。沙门氏菌，单核细胞增生李斯特氏菌和大肠杆菌O157被公认为是主要的食源性病原体，因为它们继续与诸如乳制品之类的高度受欢迎的食品相关联。最重要的是，这些病原体具有很高的流行率和死亡率，并参与了最近的几次暴发（Lynch等，2006）。多病原体富集培养基可提供营养物质和稳定的pH条件，以提高单核细胞增生李斯特菌沙门氏菌的回收率。和大肠杆菌O157细胞。