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商品描述

CCND1 Split CISH Probe
Product Code:
CS0004
Pack Size:
100 uL
Form:
DNA/RNA
Storage Temp:
Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
Product Type:
CISH Probes
Description:
CCND1 Split CISH Probe is designed for the qualitative detection of human CCND1 gene at 11q13.3 in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Hybridization signals of digoxigenin-labeled polynucleotides appear dark green distinct dot-shaped (proximal to the CCND1 breakpoint region), and dinitrophenyl-labeled polynucleotides appear bright red distinct dot-shaped (distal to the CCND1 breakpoint region).Normal situation: In interphases of normal cells or cells without a translocation involving the CCND1 gene region, two green/red fusion signals appear.Aberrant situation: One CCND1 gene region affected by a translocation is indicated by one separate green signal and one separate red signal.Other signal distribution may be observed in some abnormal samples which might result in a different signal pattern than described above, indicating variant rearrangements.Unexpected signal patterns should be further investigated.
Reagent Provided:1. Digoxigenin-labeled polynucleotides, which target sequences mapping in 11q13.3* (chr11:68,522,105-68,705,283) proximal to the CCND1 breakpoint region.2. Dinitrophenyl-labeled polynucleotides, which target sequences mapping in 11q13.3* (chr11:69,453,301-70,031,240) distal to the CCND1 breakpoint region. 3. Formamide based hybridization buffer.*according to Human Genome Assembly GRCh37/hg19
Supplier:
Abnova Corporation
Product Category:
Molecular Biology > DNA Marker
Product Code:
CS0004 Price (100 uL):
£1,070.00 excluding VATPrice (200 uL): £1,509.00 Excluding VAT
Quantity: Add to basket