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Biocare Medical/CD137/ACI 3201 A/0-1-ml

价格
¥1980.00
货号:ACI3201A
浏览量:127
品牌:Biocare
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商品描述

CD137,amemberofthetumornecrosisfactorreceptorsuperfamily,representsapromisingtargetforenhancingantitumorimmuneresponses(1).ThefunctionsofCD137inTlymphocytesincluderegulatingactivation,proliferationandapoptosis(2).CD137helpsregulatetheactivationofmanyimmunecells,includingCD4(+)Tcells,CD8(+)Tcells,dendriticcells,andnaturalkillercells.Recentstudiesindicatethattheantitumorefficacyoftherapeutictumor-targetingantibodiescanbeaugmentedbytheadditionofagoNISTicantibodiestargetingCD137.AsligationofCD137providesacostimulatorysignalinmultipleimmunecellsubsets,CD137antibodyhaspotentialtoimprovecancertreatment,andhasbeenimplicatedinbreastcancer,melanomaandlymphoma(3-5).Therefore,CD137agonistsrepresentapromisingimmunotherapeuticapproachtotreatingcancers.

Format

Concentrate,Predilute

Volume

0.1ml,0.5ml,6.0ml

Source

MouseMonoclonal

ByLetter

C

Antigen

Ectodomainofhuman4-1BBrecombinantprotein

Clone

BBK-2

IntendedUse

IVD

Isotype

IgG1/kappa

Localization

Cellsurface

PositiveControl

SmallintestinewithPeyer’spatches,tonsil

SpeciesReactivity

Human;othersnottested

References:

1.YonezawaA,etal.Boostingcancerimmunotherapywithanti-CD137antibodytherapy.ClinCancerRes.2015Jul15;21(14):3113-20.
2.HurtadoJC,etal.Potentialroleof4-1BBinTcellactivation.ComparisonwiththecostimulatorymoleculeCD28.JImmunol.1995Oct1;155(7):3360-7.
3.MartinetO,etal.Tcellactivationwithsystemicagonisticantibodyversuslocal4-1BBligandgenedeliverycombinedwithinterleukin-12erADIcatelivermetastasesofbreastcancer.GeneTher.2002Jun;9(12):786-92.
4.LiSY,LiuY.ImmunotherapyofmelanomawiththeimmunecostimulatorymonoclonalantibodiestargetingCD137.ClinPharmacol.2013Sep2;5(Suppl1):47-53.
5.ZhaoS,etal.CD137ligandisexpressedinprimaryandsecondarylymphoidfolliclesandinB-celllymphomas:diagnosticandtherapeuticimplications.AmJSurgPathol.2013Feb;37(2):250-8.
6.CenterforDiseaseControlManual.Guide:SafetyManagement,NO.CDC-22,Atlanta,GA.April30,1976“DecontaminationofLaboratorySinkDrainstoRemoveAzideSalts.”
7.ClinicalandLaboratoryStandardsInstitute(CLSI).ProtectionofLaboratoryWorkersfromOccupationallyAcquiredInfections;ApprovedGuideline-FourthEditionCLSIdocumentM29-A4Wayne,PA2014.

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