IDE-1 is an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells. It functions in part via activation of TGF-β signaling, as evident by Smad2 phosphorylation. IDE-1 Induces definitive endoderm formation in mouse and human embryonic stem cells (EC50 = 125 nM).

CAS Number

1160927-48-9

Chemical Formula

C15H18N2O5

Chemical Name

(Z)-2-((2-(6-carboxyhexanoyl)hydrazono)methyl)benzoic acid

Molecular Weight

306.31

QC Specifications

MASS Spec

Mouse ESC culture for toxicity

Shipping Information

on blue ice

Storage

4°C protected from light

Stability

Stable for up to 6 months from date of receipt when stored as directed.

Reference

1.Borowiak et al (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4 348.