Product information "BAPTA AM"
BAPTA (Cay-11706) is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 µM), with selectivity over magnesium ions or protons. BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases. It is commonly used at 10-100 µM to evaluate the role of intracellular calcium in cell signaling. It can also be used in animals. BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 µM, respectively).
Keywords: | BAPTA Acetoxymethyl ester, N,N"-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-1,1"-bis[(acetyloxy)methyl] ester-glycine |
Supplier: | Cayman Chemical |
Supplier-Nr: | 15551-5 |
Properties
Application: | Cell permeable calcium chelator |
MW: | 764.7 D |
Formula: | C34H40N2O18 |
Purity: | >98% |
Format: | Crystalline Solid |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: | |
H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution Our products are for laboratory research use only: Not for administration to humans!
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