| Human Angiopoietin 4 / ANG4 / ANGPT4 Protein (His Tag) |
Sample solution is provided at 25 µL, 10mM.
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Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.| Synonym | ANGPT4, ANG3, ANG4 |
| Protein Construction | A DNA sequence encoding the human ANGPT4 (NP_068769.2) (Met282-Ile503) was expressed, with an N-terminal polyhistidine tag. |
| Source | Human |
| Expression Host | Human Cells |
| Purity | >80 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Stability | Samples are stable for up to twelve months from date of receipt at -70℃ |
| Predicted N terminal | His |
| Molecular Mass | The recombinant human ANGPT4 comprises 242 amino acids and has a predicted molecularmass of 27.6 kDa. The apparent molecular mass of the protein isapproximately 38 kDa in SDS-PAGE under reducingconditions due to glycosylation. |
| Formulation | Lyophilized from sterile PBS, pH7.4.
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| Storage | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
| MSTN / GDF8 Protein Description | Angiopoietin 4, also known as ANG-4 or ANGPT4, is a protein belongingto the angiopoietin family and is highly expressed inthe lung with much lower levels found in other tissues. Angiopoietin 4 / ANG-4 / ANGPT4 is a protein withimportant roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to anendothelial cell-specific tyrosine-protein kinasereceptor. The mechanism by which they contribute to angiogenesis is thought toinvolve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by thisgene functions as an agonist and is an angiopoietin. Angiopoietin 4 secreted ligand for the vascular endothelial restricted receptortyrosine kinase TEK,including phosphorylation of TEK,promoting angiogenic remodeling as well as vesselmaturation and stabilization,predominantly expressed in lung. |
