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蚂蚁淘在线 / 品牌中心 / ApexBio / ApexBio/DiscoveryProbe™ Endocrinology and Hormones-related Compounds Panel/5mg/well/L1008
商品描述
Related Products
- AZD1981
- Andarine
- Fulvestrant (ICI 182,780)
- Erteberel (LY500307)
- XCT790
- ADL5859 HCl
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| DiscoveryProbe™ Endocrinology and Hormones-related Compounds Panel |
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| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles | |
| A2150 | Andarine | Selective androgen receptor agonist | Endocrinology and Hormones|Androgen Receptor | 401900-40-1 | C(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O | |
| B1534 | AZD1981 | CRTh2 antagonist,potent and selective | Endocrinology and Hormones|CRTH2 | 802904-66-1 | CC1=C(C2=C(N1CC(=O)O)C=CC=C2NC(=O)C)SC3=CC=C(C=C3)Cl | |
| A1428 | Fulvestrant | Estrogen receptor antagonist,high affinity | Endocrinology and Hormones|Estrogen/progestogen Receptor | 129453-61-8 | CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F | |
| B1518 | Erteberel (LY500307) | Erβ agonist, potent and selective | Endocrinology and Hormones|Estrogen/progestogen Receptor | 533884-09-2 | C1CC2C(C1)C3=C(C=CC(=C3)O)OC2C4=CC=C(C=C4)O | |
| B3238 | XCT790 | ERRα agonist | Endocrinology and Hormones|Estrogen/progestogen Receptor | 725247-18-7 | COC1=C(C=CC(=C1)C=C(C#N)C(=O)NC2=NN=C(S2)C(F)(F)F)OCC3=C(C=C(C=C3)C(F)(F)F)C(F)(F)F | |
| A2986 | ADL5859 HCl | δ-opioid receptor agonist,selective | Endocrinology and Hormones|Opioid Receptor | 850173-95-4 | CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=C2C(=CC=C4)O.Cl | A8456 | JTC-801 | KOR-3 (NOP) receptor antagonist, high affinity and selective | Endocrinology and Hormones|Opioid Receptor | 244218-51-7 | CCC1=CC=C(C=C1)OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C3)N=C(C=C4N)C.Cl | A8019 | Perindopril Erbumine | Potent angiotensin-converting enzyme (ACE) inhibitor | Endocrinology and Hormones|RAAS | 107133-36-8 | CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O.CC(C)(C)N |
| Download the Endocrinology and Hormones-related Compounds Panel - XLSXDownload the Endocrinology and Hormones-related Compounds Panel - SDF | ||||||
Related Biological Data
KLK3 (top) and NKX3-1(bottom) expression which were the AR target genes in various resistant clones were analyzed by QPCR.All lines were pretreated with vehicle (−) or doxycycline (+) for 3 days before treatment with DMSO (left) or 10 μmol/L MDV3100 (right) for 24 hours in 10% FCS. TBP was used to normalize expression. Data represent mean ± SEM; n = 3. *, P < 0.05;="" **,="" p="">< 0.01="" (student="" t="" test).="" the="" f876l="" mutation="" is="" sufficient="" to="" induce="" genetic="" and="" phenotypic="" resistance="" to="" mdv3100.="">
Review (Georgia Regents University)
Comparison of different anti-androgen/AR compounds on TGF-β1/Smad3/MMP9 signaling in PCa cells. CWR22Rv1 cells treated with 10 μM CASO, 10 μM MDV, 10 μM ASC, 5 μM CTS, or vehicle for 3 days were harvested. The expressions of TGF-β1, p-Smad3, Smad3, MMP9, and GAPDH were analyzed by Western blot analysis. All of the experiments have been repeated twice independently. *, p< 0.05;="" **,="" p="">< 0.01;="" ***,="" p="">< 0.001.="" error="" bars,="" s.d.="" casodex="" and="" mdv3100="" enhanced="" tgf-beta,="" mmp9="" expression="" in="" cwr22rv1="" cells.="" whereas="" asc-j9="" and="" cts="" treatment="" did="" not.="">
Review (University of Glasgow )
Chronic exposure to ENZA resulted in autophagy. To mimic resistant to ENZA, C4-2B cells were subjected to 20 μM ENZA over a period of 3 months and selected for a sub-population of resistance cells (C4-2B+R). Upper panel showed acridine orange staining of autophagosome acidic vesicles as a marker for autophagy. Lower panel showed LC3-I/II protein expression in parental cells (control) and under chronic ENZA exposure-treated vehicle control, chloroquine (CQ) or CMI. β -Actin was used as the loading control.
" to show IC50- Available in stock with overnight delivery and free shipping over $500
- Cost-effective and competitive price to save your findings
- Potent, selective and cell-permeable in inhibiting or activating target molecules
- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
- Detailed files describing potency, selectivity and applications etc.
- Supported by published data from top peer-reviewed journals
- Guaranteed high quality with NMR and HPLC validation
| Solubility | Soluble in DMSO | Storage | Desiccate at -20°C |
| Packaging | 96 well plate | Form | Powder |
| General tips | For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request | ||
A wide range of well-characterized bioactive molecules that covers various targets related to endocrinology and hormones, including androgen receptor, estrogen/progestogen receptor and RAAS etc. Facilitate your research towards the insights of diabetes, thyroid disorders and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.
1. Kaarbø M, Klokk TI, Saatcioglu F. Androgen signaling and its interactions withother signaling pathways in prostate cancer. Bioessays. 2007 Dec;29(12):1227-38.Abstract The androgen receptor (AR) is required for prostate cancer growth in all stages. This review focuses on AR function and AR-target genes and summarizes the major signaling pathways implicated in prostate cancer progression, their crosstalk with each other and with AR signaling. This complex network of interactions is providing a deeper insight into prostate carcinogenesis and may form the basis for novel diagnostic and therapeutic strategies.
