品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com

ApexBio/DiscoveryProbe™ Apoptosis-related Compounds Panel/5mg/well/L1002

价格
¥43980.00
货号:L1002
浏览量:127
品牌:ApexBio
服务
全国联保
正品保证
正规发票
签订合同
商品描述
Related Products
  • ABT-263 (Navitoclax)
  • Q-VD-OPh hydrate
  • MIM1
  • ABT-199
  • UMI-77
Molarity CalculatorDilution Calculator
DiscoveryProbe™ Apoptosis-related Compounds Panel

Catalog No.L1002
SizePriceStockQty
5mg/well
$2,199.00
In stock

Tel: +1-832-696-8203

Email: sales@apexbt.com

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Click and Customize the Panelwith your own choices of compounds/size/quantities/chemical forms etc.

Publications citing ApexBio Products

Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.
Nature.2018 Jun 13.
Nature.2018 Jun 27.
Nature.2018 Mar 29;555(7698):673-677.
Nature.2017 Sep 7;549(7670):96-100.
Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8
Nat Nanotechnol.2017 Dec;12(12):1190-1198.
Nature Biotechnology.2017 Jun;35(6):569-576
Nat Med.2018 Sep 17.
Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.
Cell.Available online 25 October 2018.
Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.
Cell.2018 Jun 28;174(1):172-186.e21.
Cell.2018 Feb 22;172(5):1007-1021.e17.
Cell.2017 Nov 30;171(6):1284-1300.e21.
Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.
Cell.2017 Jul 13;170(2):312-323
Nat Med.2018 Jan 29.
Nat Med.2017 Nov;23(11):1342-1351.
Cell.2017 Apr 6;169(2):286-300.
Cell.2015 Aug 27;162(5):987-1002.
Cell.2015 Feb 12;160(4):729-44.
Nature Medicine.2017 Apr;23(4):493-500.
Cancer Cell.2018 May 14;33(5):905-921.e5.
Cancer Cell.2018 Apr 9;33(4):752-769.e8.
Cancer Cell.2018 Mar 12;33(3):401-416.e8.
Cancer Cell.2017 Aug 14;32(2):253-267.e5.
Nat Methods.2018 Jul;15(7):523-526.
Cell Stem Cell.2018 May 3;22(5):769-778.e4.
Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.

HTS Facility Partners

HTS Facility Partners

Featured Products of the Panel

Catalog No.Product NameSummaryTargetsCAS NumberSmiles
A3007ABT-263 (Navitoclax)Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-wApoptosis|Bcl-2 Family923564-51-6CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
A4465MIM1Mcl-1 InhibitorApoptosis|Bcl-2 Family OC1=CC=C(/C=N/N2C(C)=CS/C2=NC3CCCCC3)C(O)=C1O
A8194ABT-199Bcl-2 inhibitor,potent and selectiveApoptosis|Bcl-2 Family1257044-40-8CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
B4881UMI-77Mcl-1 inhibitorApoptosis|Bcl-2 Family518303-20-3C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br
A1901Q-VD-OPh hydrateCell-permeable, irreversible pan-caspase inhibitorApoptosis|Caspase1135695-98-5CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2
A1902Z-VAD-FMKCell-permeable, irreversible pan-caspase inhibitorApoptosis|Caspase187389-52-2CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
Download the Apoptosis related Compounds Panel - XLSXDownload the Apoptosis related Compounds Panel - SDF

Quality Control

Related Biological Data

 ABT-263
ABT-737, or ABT-263 at the indicated doses for 24 hours. Survival data are shown for transitional B cells (n = 3 mice for each genotype) and are the results of 3 independent experiments, each performed in triplicate. Experiments depicted in panels C and D were performed concurrently. Values represent mean ± SEM.

Related Biological Data

 ABT-263
As an inhibitor of Bcl-2, ABT263 is effective to reduce cell viability in HG3-CLL cells. Incubating the cells with ABT263 in 96 well plates (3×104 cells per well) for 24h shows a dose-dependent inhibition of cell viability with EC50 value of 2μM.[Source: Istituto di Scienze dell’Alimentazione]

Related Biological Data

Z-VAD-FMK
zVAD was able to completely suppress the proteolytic processing of Panx1 at each incubation time point in the anti-Fas treated Jurkat cells [1].
1. Boyd-Tressler A, Penuela S, Laird D W, et al. Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-Independent Mechanism. Journal of Biological Chemistry, 2014: jbc. M114. 590240.

Related Biological Data

Z-VAD-FMK

Related Biological Data

Z-VAD-FMK

Related Biological Data

Z-VAD-FMK

Signaling Pathway

Caspase Research Area
P53 Research Area
Bcl-2 Family Research Area

Advantages

  • Available in stock with overnight delivery and free shipping over $500
  • Cost-effective and competitive price to save your findings
  • Potent, selective and cell-permeable in inhibiting or activating target molecules
  • Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
  • Detailed files describing potency, selectivity and applications etc.
  • Supported by published data from top peer-reviewed journals
  • Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

SolubilitySoluble in DMSOStorageDesiccate at -20°C
Packaging96 well plateFormPowder
General tipsFor obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping ConditionEvaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets related to apoptosis, including caspase, MDM2 and Bcl-2 etc. Facilitate your research towards the insights of cancer, degenerative diseases and autoimmunity etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Fuchs Y, Steller H. Programmed cell death in animal development and disease.Cell. 2011 Nov 11;147(4):742-58. doi: 10.1016/j.cell.2011.10.033. Review. Erratumin: Cell. 2011 Dec 23;147(7):1640.Abstract Programmed Cell Death (PCD) plays a fundamental role in animal development and tissue homeostasis. We focus on the function and regulation of apoptotic proteins, including caspases, the key executioners of apoptosis, highlighting the functions of these proteins in cell differentiation and tissue remodeling. Finally, we explore the connections between apoptosis, stem cells and cancer, focusing on how apoptotic cells release a variety of signals to communicate with their cellular environment, including factors that promote cell division, tissue regeneration, and wound healing.
2. Abrams MJ, Basinger T, Yuan W, Guo CL, Goentoro L. Self-repairing symmetry in jellyfish through mechanically driven reorganization. Proc Natl Acad Sci U S A.2015 Jun 30;112(26):E3365-73.Abstract In this study, we report a previously unidentified strategy of self-repair, where moon jellyfish respond to injuries by reorganizing existing parts, and rebuilding essential body symmetry, without regenerating what is lost. we find that forces generated by the muscular network are essential for symmetrization. Furthermore, decreasing pulse frequency using muscle relaxants slowed symmetrization, whereas increasing pulse frequency by lowering the magnesium concentration in seawater accelerated symmetrization. Self-repair in Aurelia proceeds through the reorganization of existing parts, and is driven by forces generated by its own propulsion machinery.
ApexBio的3X FLAG Peptide FLAG标签系统利用与目标蛋白质1融合的短而亲水的8个氨基酸的肽段。FLAG肽与抗体M1结合。结合是钙依赖性方式2还是非依赖性3仍存在争议。该系统的缺点是单克隆抗体纯化基质不如其他基质稳定。通常,可以用特异性单克隆抗体检测小标签。为了改善对FLAG标签的检测,已经开发了3x FLAG系统。这种三级FLAG表位是亲水的,长22个氨基酸,可以检测到高达10 fmol的表达融合蛋白。激烈热球菌的带有FLAG标签的麦芽糖糊精结合蛋白已被结晶4,其晶体质量与未标记蛋白的晶体质量非常相似。 最后,可以通过用肠激酶处理去除FLAG标签,肠激酶对肽序列5的5个C末端氨基酸具有特异性。