| ML-356thioesterase domain of fatty acid synthase (FAS-TE) inhibitor |
Sample solution is provided at 25 µL, 10mM.
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- Purity = 98.00%
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| Cas No. | 1808260-45-8 | SDF | Download SDF |
| Chemical Name | 2-ethyl-N-[4-[4-(4-morpholinylsulfonyl)phenyl]-2-thiazolyl]-butanamide | ||
| Canonical SMILES | O=S(C1=CC=C(C2=CSC(NC(C(CC)CC)=O)=N2)C=C1)(N3CCOCC3)=O | ||
| Formula | C19H25N3O4S2 | M.Wt | 423.5 |
| Solubility | ≤0.5mg/ml in ethanol;20mg/ml in DMSO;10mg/ml in dimethyl formamide | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
ML-356 is an inhibitor of the thioesterase domain of fatty acid synthase with IC50 value of 334 nM.
Fatty acid synthase (FAS) is a multi-enzyme protein that catalyzes fatty acid synthesis, fatty acids are related to energy production and storage, cellular structure ,hormones biosynthesis .A number of subsequent immunohistochemically analyses showed that increased expression of FAS is a hallmark of all major cancers including those of the prostate, the breast, the colon, and the ovaries.
In prostate cancer PC-3 cells, ML-356 blocked palmitate (the final product of fatty acids synthesis) biosynthesis, indicating that ML-356 has potential to block tumor growth in vivo because FAS is up-regulated in all the major solid tumors.
Reference:1. R. Ardecky, M. P. Hedrick, P. Gosalia, et al. Selective inhibitors of FAS-TE. Probe Reports from the NIH Molecular Libraries Program (2010).
