| AH 6809EP and DP receptor antagonist |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
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- Purity = 98.00%
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| Cas No. | 33458-93-4 | SDF | Download SDF |
| Synonyms | AH6809;AH-6809 | ||
| Chemical Name | 9-oxo-6-propan-2-yloxyxanthene-2-carboxylic acid | ||
| Canonical SMILES | CC(C)OC1=CC2=C(C=C1)C(=O)C3=C(O2)C=CC(=C3)C(=O)O | ||
| Formula | C17H14O5 | M.Wt | 298.29 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
AH 6809 is an antagonist of prostaglandin receptor EP1, EP2 and D2 [1].
In COS-7 cells transfected with human EP2 receptor, AH 6809 treatment selectively inhibited the cAMP production increased by PGE2 but not forskolin. In the non-small cell lung cancer NCI-H1299 cell line, AH 6809 inhibited the binding of 3H-PGE2 to the cell membrane with IC50 value of 5 μM. The compound also inhibited the increase in cAMP level caused by PGE2 in NCI-H1299 cells. Moreover, AH 6809 significantly suppressed the cell proliferation and colony formation at low micromolar concentration. Besides that, AH 6809 exerted to be a specific DP-receptor blocking drug. It inhibited the anti-aggregation activity of PGD2 in whole blood [1, 2 and 3].
References:1.Woodward D F, Pepperl D J, Burkey T H, et al. 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2receptor antagonist. Biochemical pharmacology, 1995, 50(10): 1731-1733. 2.Qian X, Zhang J, Liu J. Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway. Journal of Biological Chemistry, 2011, 286(3): 2111-2120. 3.Ito S, Okuda E, Sugama K, et al. Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. British journal of pharmacology, 1990, 99(1): 13-14.
