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PBL/Anti-Human IFNAR2 Antibody, Clone MMHAR-2, neutralizing (MAb)/50 μg/21385-1

价格
¥9900.00
货号:21385-1
浏览量:127
品牌:pblassaysci
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商品描述

Anti-Human IFNAR2 Antibody, Clone MMHAR-2, neutralizing (MAb)

Product Features:
  • Anti-IFNAR2 antibody (clone MMHAR-2) to human Interferon (Alpha, Beta and Omega) Receptor 2
  • Blocks the biological action of Human Type I Interferons
  • Suitable for use in Type I IFN neutralization, flow cytometry, immunohistochemistry, and immunoprecipitation

Full Product Name: Anti-Human Interferon Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)

Ordering

Catalog No. Pack Size Price Quantity
21385-1

50 μg

$495.00
$575.00
  • Specifications
  • Tech Info / Data
  • Citations
  • Documentation

Specifications

FormulationSupplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
AntigenHuman interferon alpha/beta receptor chain 2 (Human IFNAR2)
IsotypeIgG2A
Host SpeciesMouse
Purity> 95% by SDS-PAGE stained by Coomassie BlueEndotoxin level < 1 EU/μg
BioactivityMeasured by neutralization of interferon in cytopathic effect inhibition assay.
SpecificityNeutralizes human IFN-alpha receptor; interacts with extracellular domain; binds to human IFN-alpha receptor with high affinity; blocks biological action of Type I IFNs
StorageFor retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Antigen SynonymsNone
CloneMMHAR-2

Tech Info / Data

Tested Applications:

  • Neutralization

Suggested Applications*:

  • Immunoprecipitation (1-5 μg/ml)
  • Immunohistochemistry (1 μg/ml)
  • Flow Cytometry (1-10 μg/ml)

*Please note that these applications are presented for suggested use only and have not been fully evaluated by PBL.

 

Background:

The Type I interferon receptor is a heterodimer consisting of IFNAR1 and IFNAR2. The IFNAR2 subunit provides most of the binding affinity for IFN and IFNAR1 is required for optimum signaling.

Citations

Documentation

Neutralization Effect of PBL Anti-Human IFNAR2 Monoclonal Antibody (21385) on Human IFN Alpha 2a (11100) and IFN Beta (11415) Activities in an A549 Cell/EMCV CPE Assay

 

Image depicting PBL Anti-Human IFNAR2 Monoclonal's neutralizing effect on Human IFN Alpha and IFN Beta protection of A549 cells from the cytopathic effect of EMCV infection
PBL分析开发服务可以根据您的特定需求量身定制。分析方法被开发用于研究用途或支持后续GLP验证的标准。 您可以确信,PBL将提供可行的解决方案,从而在开发项目期间最大程度地提高您样本中的数据。我们将与您一起确定必要的步骤,所需的试剂并在潜在问题发生之前确定它们。从原理证明到技术转让,我们的经验将确保我们为您的特定应用需求提供强大而灵敏的测定解决方案。 基于细胞的分析开发 提供但不限于基于细胞的分析开发服务,包括:定制的细胞病变作用,抗增殖和生长促进测定开发报告基因系统或鉴定细胞系以监测目标化合物的活性抗体对生物活性的中和,与鉴定生物活性单克隆抗体(MAb)和监测免疫原性有关免疫分析开发 定制的免疫测定和ELISA支持:药代动力学和药效学研究毒性和免疫原性研究直接,夹心或竞争性ELISA分析开发分析优化服务 特异性和交叉反应性评估分析和动态范围优化减少基质效应(血清,血浆,组织培养基)减少批内和批内变异性标准校准分析稳定性评估协议优化