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Advanced immunochemical/Monoclonal mouse anti-human recombinant interferon beta/0.2 mg/2-IFB

价格
¥4340.00
货号:2-IFB
浏览量:112
品牌:Advanced immunochemical
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商品描述

General Category:

    Monoclonal antibodies » Inflammation » Cytokines

Disease Category:

    Inflammation
      Inflammation » Cytokines
MAbs:
BB4, BD9, BF3Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with human recombinant full-size interferon β, expressed in E. coli.
Specificity:
MAbs BB4, and BD9 recognize non-glycosylated (expressed in E. coli) and glycosylated(expressed in CHO) recombinant human interferon β antigens. MAb BF3 recognizes only nonglycosylated interferon β. There is no cross-reactivity with human interferon ⍺ or human interferon γ.
MAb Isotypes:
IgG1 for MAb BF3IgG2a for MAbs BB4 and BD9
Applications:
Antibodies are working in ELISA and Western blotting.MAbs BB4 and BF3 can be used for coating and MAbs BD9 and BG6 can be used as conjugates in sandwich ELISA.MAbs BD9 have neutralizing activity in Western blotting.
Purification:
Chromatography on protein G Sepharose
Presentation:
PBS, pH 7.4, 0.1 % sodium azide (NaN3)
Storage Conditions:
+ 4 °C
Material Safety Note:
This product is sold as an antibody preparation for research use only. Standard Laboratory Practices should be followed when handling this material.Contains sodium azide (0.1 %) as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Advanced immunochemical高敏C反应蛋白人C反应蛋白(CRP)是所谓的急性期蛋白之一。它在血液中的浓度随着对炎症的反应而迅速增加。CRP是224个残基蛋白,单体分子量约为25 kDa,pI 6.4(1-4)。它属于五味子毒素,这是一种进化保守的蛋白质家族,其特征在于钙依赖性配体结合和五个单体的对称性,这些单体在中心孔周围形成一个环(5)。CRP在体内的确切功能尚不完全清楚。已证明CRP参与炎症以及先天免疫过程。CRP的重要生物活性取决于其与各种配体(例如受损细胞膜,凋亡细胞和纤连蛋白)的结合能力,对磷胆碱残基的亲和力最高。当CRP与配体结合时,它可以被补体成分C1q识别,从而激活经典补体途径。另一方面,CRP通过与补体因子H相互作用来调节替代补体途径