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Advanced immunochemical/Monoclonal mouse anti- Insulin-like growth factor binding protein 4 (IGFBP-4)/0.2 mg/2-IGFBP4

价格
¥8580.00
货号:2-IGFBP4
浏览量:41
品牌:Advanced immunochemical
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商品描述

General Category:

    Monoclonal antibodies » Cardiac Markers » IGFBP-4Monoclonal antibodies » Tumor Markers

Disease Category:

    Cardiac Markers » Monoclonal antibodies » IGFBP-4Tumor Markers » Monoclonal antibodies
MAbs:
IBP144, IBP182, IBP190New MAbs: IBP3, IBP154, IBP163, IBP180, IBP185Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cellsof Balb/c mice immunized with recombinant human IGFBP-4 expressed in mammalian cell line(MAbs IBP144, IBP182, IBP190, IBP180, IBP185, IBP154), synthetic peptide from human IGFBP-4His142- Met156 (MAb IBP3) or synthetic peptide from human IGFBP-4 Lys157-Gln171 (MAb IBP163).
Specificity:
MAbs IBP144, IBP154 and IBP180:human IGFBP-4; human N-terminal IGFBP-4 fragment (NT-IGFBP-4)MAbs IBP182, IBP185 and IBP190:human IGFBP-4; human C-terminal IGFBP-4 fragment (CT-IGFBP-4)MAb IBP3:human NT-IGFBP-4, cross-reaction with full-length human IGFBP-4MAb IBP163:human CT-IGFBP-4, cross-reaction with full-length human IGFBP-4 <5% (ELISA)
MAb Isotypes:
IgG1 for MAbs IBP163, IBP190IgG2a for MAbs IBP144, IBP154, IBP180 IgG2b for MAb IBP182, IBP185 IgG3 for MAb IBP3
Applications:
Detection of human IGFBP-4, NT-IGFBP-4, and CT-IGFBP-4. MAbs are working in direct ELISA and sandwich immunoassay.Recommended pairs for human IGFBP-4 sandwich immunoassay (capture-detection): IBP185 –IBP154 IBP182 – IBP144 IBP144 – IBP190 Recommended pairs for specific human NT-IGFBP-4 sandwich immunoassay (capture-detection):IBP3 – IBP144 IBP3 – IBP180 Recommended pairs for specific human CT-IGFBP-4 sandwich immunoassay (capture-detection): IBP182 – IBP163
Purification:
Chromatography on protein A Sepharose
Presentation:
PBS, pH 7.4, 0.1 % sodium azide (NaN3)
Storage Conditions:
+ 4 °C
Material Safety Note:
This product is sold as an antibody preparation for research use only. Standard Laboratory Practices should be followed when handling this material.Contains sodium azide (0.1 %) as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Advanced immunochemical高敏C反应蛋白人C反应蛋白(CRP)是所谓的急性期蛋白之一。它在血液中的浓度随着对炎症的反应而迅速增加。CRP是224个残基蛋白,单体分子量约为25 kDa,pI 6.4(1-4)。它属于五味子毒素,这是一种进化保守的蛋白质家族,其特征在于钙依赖性配体结合和五个单体的对称性,这些单体在中心孔周围形成一个环(5)。CRP在体内的确切功能尚不完全清楚。已证明CRP参与炎症以及先天免疫过程。CRP的重要生物活性取决于其与各种配体(例如受损细胞膜,凋亡细胞和纤连蛋白)的结合能力,对磷胆碱残基的亲和力最高。当CRP与配体结合时,它可以被补体成分C1q识别,从而激活经典补体途径。另一方面,CRP通过与补体因子H相互作用来调节替代补体途径