General Category:

Antigens » Neuroscience

Disease Category:

Neuroscience » Antigens

Source:

Human brain tissue.Blood samples from tissue donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV, and syphilis.

Applications:

Biochemical and immunochemical investigations.

Analysis:

Purity > 95 % (native PAGE in reducing conditions with EGTA).

Purification:

Ion-exchange chromatography followed by gel-filtration.

Presentation:

Lyophilized from protein solution with 2 mM EDTA.Product is recommended to reconstitute with distilled water.

Storage Conditions:

-20 °C (between -15 and -30 °C allowed)

Material safety note:

This product is sold for research use only. Standard Laboratory Practices should be followed when handling this material.

Advanced immunochemical高敏C反应蛋白人C反应蛋白（CRP）是所谓的急性期蛋白之一。它在血液中的浓度随着对炎症的反应而迅速增加。CRP是224个残基蛋白，单体分子量约为25 kDa，pI 6.4（1-4）。它属于五味子毒素，这是一种进化保守的蛋白质家族，其特征在于钙依赖性配体结合和五个单体的对称性，这些单体在中心孔周围形成一个环（5）。CRP在体内的确切功能尚不完全清楚。已证明CRP参与炎症以及先天免疫过程。CRP的重要生物活性取决于其与各种配体（例如受损细胞膜，凋亡细胞和纤连蛋白）的结合能力，对磷胆碱残基的亲和力最高。当CRP与配体结合时，它可以被补体成分C1q识别，从而激活经典补体途径。另一方面，CRP通过与补体因子H相互作用来调节替代补体途径