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Advanced immunochemical/Lipoprotein-associated phospholipase A2 (Lp-PLA2), In vitro, antibody/0.2 mg/2-LP2iv

价格
¥6800.00
货号:2-LP2iv
浏览量:127
品牌:Advanced immunochemical
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商品描述

General Category:

    Monoclonal antibodies » Cardiac MarkersMonoclonal antibodies » Metabolic Syndrome

Disease Category:

    Cardiac MarkersMetabolic Syndrome
      Metabolic Syndrome » Monoclonal Antibodies
MAbs:
PL4cc, PL26cc, PL42cc, PL46cc

Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with recombinant human Lp-PLA2.

MAb Isotypes:
IgG1 for MAbs PL4cc, PL26cc, PL42cc, PL46cc
Applications:
Sandwich immunoassay, Western blottingRecommended pairs for Lp-PLA2 sandwich immunoassay for detecting Lp-PLA2 in human serum and plasma (capture – detection):PL42cc – PL46ccPL26cc – PL46ccPL26cc – PL4ccMAb PL26cc reacts with Lp-PLA2 in Western blotting.
Purification:
Chromatography on protein A Sepharose
Presentation:
PBS, pH 7.4, 0.09 % sodium azide (NaN₃)
Storage Conditions:
+4 °C (+2 … +8 °C allowed)
Recommendation:
Replace bovine serum albumin (BSA) with 1% casein as a buffer component or to use blocking agent in Lp-PLA2 immunoassay.Blocking of the immunoassay plates with casein is needed to prevent non-specific binding of Lp-PLA2 to the plate surface.
Material safety note:
This product is sold for research use only. Standard Laboratory Practices should be followed when handling this material.Product contains sodium azide as a preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

Advanced immunochemical高敏C反应蛋白人C反应蛋白(CRP)是所谓的急性期蛋白之一。它在血液中的浓度随着对炎症的反应而迅速增加。CRP是224个残基蛋白,单体分子量约为25 kDa,pI 6.4(1-4)。它属于五味子毒素,这是一种进化保守的蛋白质家族,其特征在于钙依赖性配体结合和五个单体的对称性,这些单体在中心孔周围形成一个环(5)。CRP在体内的确切功能尚不完全清楚。已证明CRP参与炎症以及先天免疫过程。CRP的重要生物活性取决于其与各种配体(例如受损细胞膜,凋亡细胞和纤连蛋白)的结合能力,对磷胆碱残基的亲和力最高。当CRP与配体结合时,它可以被补体成分C1q识别,从而激活经典补体途径。另一方面,CRP通过与补体因子H相互作用来调节替代补体途径