- SynonymNetrin receptor DCC,DCC,IGDCC1,netrin receptor DCC
- SourceHuman Netrin receptor DCC, His Tag (NEC-H52H3) is expressed from human 293 cells (HEK293). It contains AA Phe 32 - Asn 1097 (Accession # P43146-1).Predicted N-terminus: Phe 32
- Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 119.5 kDa.
- Endotoxin
- Formulation
Please contact us for detailed information.
Contact us for customized product form or formulation.
- Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
- Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
- BackgroundReceptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
- References
- (1)K Keino-Masu, et al. Cell. 1996. 87(2):175-85.
- (2)S Miyake, et al. Cancer Res. 1994. 54(11):3007-10.
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