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Abeomics/Imidazoquinoline Resiquimod (R-848)/1mg/15-1016

价格
¥3500.00
货号:15-1016
浏览量:127
品牌:Abeomics
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商品描述

Amount :500ug, 1mg/ml
Purification :Purity≥98%
Content :liquid (1 mg/ml)
Storage condition :Store the product at 4°C for short term and at -20°C for long-term storage. Product is stable for 2 years at -20°C.
Alternative Name :Resiquimod; S 28463; R848
Formula: C17H22N4O2
MW: 314.4
Immune response modifier. Potent antitumor and antiviral compound. Stimulates antibody secretion and cytokine production. Used as adjuvant to increase the effectiveness of vaccines, potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human Activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway and leads to the induction of NF-κB,NLRP3/NALP3 inflammasome activator, independent of TLRs and RIG-I.Upregulator of the opioid growth factor receptor.Used in the treatment of skin lesions such as herpes simplex virus.

Solubility: Soluble in DMSO, dichloromethane or methanol. Slightly soluble in acetonitrile or ethyl acetate.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Abeomics的人PD-L1重组Fc融合蛋白(正在供货)CHO-K1 Celline。 PD-L1(CD274 / B7-H1)是一种重要的膜结合共刺激分子,属于B7超家族,可通过其受体抑制免疫反应,PD-1和PD-L1在炎症性疾病的发病机理中起关键作用死亡1)。它在单核吞噬细胞系统(MPS)中广泛表达,可共同刺激T细胞并调节炎症反应。PD-L1通过对T细胞功能产生负面共刺激作用来发挥炎症调节功能,以抑制细胞因子分泌,促进活化T细胞凋亡并诱导T细胞无反应。在细菌感染,炎症和许多自身免疫性疾病中,已经报道了CD274的异常表达和失调。