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Abeomics/Monoclonal Antibody to DNMT3b (Clone:ABM1C25 )/25 µg/10-7001

价格
¥1800.00
货号:10-7001
浏览量:127
品牌:Abeomics
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商品描述

Format :Purified
Amount :100 µg
Isotype :Mouse IgG1 Kappa
Purification :Protein G Chromatography
Content :25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene :DNMT3B
Gene ID :1789.
Uniprot ID :Q9UBC3
Alternative Name :DNA (cytosine-5)-methyltransferase 3B, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB
Immunogen Information :Full length recombinant protein of DNMT3bwas used as the immunogen for this antibody.

Western blot analysis: 6-8 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:Nucleus
Post transnational modification:Citrullinated by PADI4.
Tissue Specificity:Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate.
BioGrid:108126.70 interactions.
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Abeomics的人PD-L1重组Fc融合蛋白(正在供货)CHO-K1 Celline。 PD-L1(CD274 / B7-H1)是一种重要的膜结合共刺激分子,属于B7超家族,可通过其受体抑制免疫反应,PD-1和PD-L1在炎症性疾病的发病机理中起关键作用死亡1)。它在单核吞噬细胞系统(MPS)中广泛表达,可共同刺激T细胞并调节炎症反应。PD-L1通过对T细胞功能产生负面共刺激作用来发挥炎症调节功能,以抑制细胞因子分泌,促进活化T细胞凋亡并诱导T细胞无反应。在细菌感染,炎症和许多自身免疫性疾病中,已经报道了CD274的异常表达和失调。