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商品描述
SOX-1
SRY (sex determining region Y)-box 1
Download Product PDFProduct Preparation
A synthetic peptide derived from N-terminus of Human SOX-1 protein. This sequence is identical among human and mouse.
Background
The SOX1 is a transcription factor, a member of the SRY-related HMG-box (SOX) family involved in the regulation of embryonic development and in the determination of cell fate. SOX1 is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to ß-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling.
PURIFICATION The Rabbit IgG is purified by Epitope Affinity Purification | SPECIFICITY This antibody recognizes ~40 kDa of human SOX-1 protein. It also reacts with mouse.The other species are not tested. |
FORMULATION This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer. | STORAGE The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity.Avoid repeated freezing-thawing cycles. |
Gene ID
6656
Applications/Suggested Working Dilutions
Western Blot 0.1-1 µg/ml | ELISA 0.01-0.1 µg/ml | Immunoprecipitation 2-5µg/ml | IHC 2-10µg/ml | Flow cytometry 5-10µg/ml |
