品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Neurofibromin(pS2741)
NF1 neurofibromin 1
Download Product PDFProduct Preparation
A synthetic peptide surrounding the epitope –PTSPY- with a phosphorylation site of Ser2741 of human neurofibromin. This sequence is identical among human, rat, mouse, chicken, bovine and dog.
Background
The neurofibromatosis type 1 (NF1) tumor suppressor (neurofibromin) is thought to play crucial roles in cellular Ras- and cAMP-dependent kinase (PKA)-associated signals. The absence of or alteration of the neurofibromin protein may lead to neurofibromatosis disease. Recently, a cellular neurofibromin-associating protein, NG,NG-dimethylarginine dimethylaminohydrolase (DDAH)has been identified as a cellular NO/NOS regulator which increases PKA phosphorylation of native neurofibromin in a dose-dependent manner.The PKA accessibility of neurofibromin regulated via DDAH interaction may modulate the cellular function of neurofibromin that is implicated in NF1-related pathogenesis.
PURIFICATION The Rabbit IgG is purified by site-modified Epitope Affinity Purification. | SPECIFICITY This antibody recognizes ~240 kDa of human neurofibromin protein at the phosphorylation site of Ser 2741.It does not cross react to non-phospho NF1.This antibody also reacts with mouse, rat, chicken, bovine and dog.The other species are not tested. |
FORMULATION This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer. | STORAGE The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity.Avoid repeated freezing-thawing cycles. |
Gene ID
4763
Applications/Suggested Working Dilutions
Western Blot 0.1-1 µg/ml | ELISA 0.01-0.1 µg/ml | Immunoprecipitation 2-5µg/ml | IHC 2-10µg/ml | Flow cytometry 5-10µg/ml |
