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商品描述
AZD1208
- Catalog No.:MC0159
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo:
- 1204144-28-4
- MolecularFormula:
- C21H21N3O2S
- Purity:
- >98%
- Target:
- Pim
- IC50:
- No data
- In Vitro:
- AZD1208 shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. AZD1208 (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cell at 1 μM. AZD1208 induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3]
- In Vivo:
- Fields:
- AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
- Specificity:
- Target:Pim. Fields: AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
- Source:
- Rabbit
- Dilution:
- WB 1:500-2000
- Concentration:
- >98%
- Storage Stability:
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name:
- AZD-1208;, AZD1208;, AZD 1208.
- MolecularWeight(Da):
- 379.48
- References:
- [1]. Dakin LA, et al. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012 Jul 15;2
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