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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
ACTA2 Monoclonal Antibody
- Catalog No.：YM0010
- Applications：WB,IHC-p,IF(paraffin section),ELISA
- Reactivity：Human,Monkey
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- ACTA2
- Protein Name：
- Actin, aortic smooth muscle
- Human Gene Id：
- 59
- Human Swiss Prot No：
- P62736
- Mouse Swiss Prot No：
- P62737
- Immunogen：
- Purified recombinant fragment of human ACTA2 expressed in E. Coli.
- Specificity：
- ACTA2 Monoclonal Antibody detects endogenous levels of ACTA2 protein.
- Formulation：
- Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
- Source：
- Mouse
- Dilution：
- Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
- Purification：
- Affinity purification
- Storage Stability：
- -20°C/1 year
- Other Name：
- ACTA2; ACTSA; ACTVS; GIG46; Actin;aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein
- References：
- 1. Nat Genet. 2007 Dec;39(12):1488-93. 2. Virchows Arch. 2007 Dec;451(6):999-1007.
- Background：
- actin, alpha 2, smooth muscle, aorta(ACTA2) Homo sapiensThe protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008],
- Function：
- disease:Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as "medial necrosis" or "Erdheim cystic medial necrosis" in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actin
- Subcellular Location：
- extracellular space,cytoplasm,cytosol,actin cytoskeleton,lamellipodium,filopodium,smooth muscle contractile fiber,protein complex,cell body,extracellular exosome,
- Expression：
- Pituitary,Uterus,
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- September 08-2020
- FLOW-CYTOMEYRT-PROTOCOL
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
- July 13-2018
- Antibody-FAQs
- Products Images
- Western Blot analysis using ACTA2 Monoclonal Antibody against HeLa (1), and Cos7 (2) cell lysate.
- Immunohistochemistry analysis of paraffin-embedded liver tissues (left) and lung cancer tissues (right) with DAB staining using ACTA2 Monoclonal Antibody.
