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商品描述
GW788388
- Catalog No.：MC0353
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 452342-67-5
- MolecularFormula：
- C25H23N5O2
- Purity：
- >98%
- Target：
- TGF-β Receptor
- IC50：
- IC50: 18 nM (ALK5)
- In Vivo：
- GW788388 given orally for 5 weeks significantly reduces renal fibrosis and decreased the mRNA levels of key mediators of extracellular matrix deposition in kidneys in db/db mice[1]. GW788388 (50 mg/kg/day, p.o.) significantly attenuates systolic dysfunction in the MI animals, together with the attenuation of the activated (phosphorylated) Smad2 (P < 0.01),="" α-smooth="" muscle="" actin="" (p="">< 0.001),="" and="" collagen="" i="" (p="">< 0.05)="" in="" the="" noninfarct="" zone="" of="" mi="" rats[2].="" gw788388="" reduces="" the="" expression="" of="" collagen="" ia1="" by="" 80%="" at="" a="" dose="" of="" 1="" mg/kg="" twice="" a="" day="" (b.i.d.).="" gw788388="" significantly="" reduces="" the="" expression="" of="" collagen="" ia1="" mrna="" when="" administered="" orally="" at="" 10="" mg/kg="" once="" a="" day="" (u.i.d.)="" in="" a="" model="" of="" puromycin="" aminonucleoside-induced="" renal="">
- Fields：
- GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
- Specificity：
- Target:TGF-β Receptor. Fields: GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inh
- Source：
- Rabbit
- Dilution：
- IC50: 18 nM (ALK5)
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- GW 788388,GW-788388
- MolecularWeight(Da)：
- 425.48
- References：
- [1]. Petersen M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int, 2008, 73(6), 705-715.[2]. Tan SM, et al. Target
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