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商品描述
IRAK-1/4 Inhibitor
- Catalog No.：MC0893
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 509093-47-4
- MolecularFormula：
- C20H21N5O4
- Purity：
- >98%
- Target：
- IRAK
- IC50：
- IC50: 0.2 μM (IRAK-4), 0.3 μM (IRAK-1)[1]
- In Vitro：
- IRAK-1-4 Inhibitor I has IC50 greater than the highest concentration tested (10 μM) against a panel of 27 other kinases, including the most closely homologous (outside of the IRAK family) Lck and pp60SRC. Additionally, IRAK-1-4 Inhibitor I does not show any signs of cytotoxicity in a 72 h proliferation assay in HeLa cells (ED50>30 μM). Significant inhibition of IRAK-1 is observed with IRAK-1-4 Inhibitor I (IRAK-1 IC50=0.3 μM)[1]. IRAK-1/4 inhibitor eliminates the LPS-induced increases in Bcl10, NF-κB, and IL-8. IRAK-1/4 mediates LPS-induced IL-8 activation and functions upstream of Bcl10. The LPS-induced increase in Bcl10 declines by 73% (from 5.18±0.22 to 2.36±0.08 ng/mL), and the IL-8 response decline by 60% (from 2.64±0.31 to 1.14±0.08 ng/mL)[2].
- Fields：
- Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor is a benzimidazole compound that acts as a cell-permeable, potent selective inhibitor of IL-1 kinases. IC50: 0.2 μM (IRAK-4), 0.3 μM (IRAK-1)[1]
- Specificity：
- Target: IRAK . Fields: Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor is a benzimidazole compound that acts as a cell-permeable, potent selective inhibitor of IL-1 kinases. IC50: 0.2 μM (IRAK-
- Source：
- Rabbit
- Dilution：
- IC50: 0.2 μM (IRAK-4), 0.3 μM (IRAK-1)[1]
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
- MolecularWeight(Da)：
- 395.42
- References：
- [1]. Powers JP, et al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-2845. [2]. Bhattacharyya S, et al. Bcl10 me
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