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商品描述
Doxorubicin hydrochloride
- Catalog No.：MC0051
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 25316-40-9
- MolecularFormula：
- C27H29NO11.HCl
- Purity：
- 99%
- Target：
- Topoisomerase
- IC50：
- No data
- In Vitro：
- Combination of Doxorubicin and Simvastatin in the highest tested concentrations (2 μM and 10 μM, respectively) kills 97% of the Hela cells[2].
- In Vivo：
- Mice bearing PC3 xenografts are injected with 2, 4 or 8 mg/kg Doxorubicin and tumor volume is measured over time. A dose of 2 mg/kg does not affect tumor growth while higher dosages delay tumor growth initially (p<0.05 at="" days="" 18="" and="" 22),="" 4="" mg/kg="" or="" 8="" mg/kg="" doxorubicin="" significantly="" reduces="" levels="" of="" c-flip="" in="" pc3="" xenografts[3].="" a="" single="" intraperitoneal="" injection="" 10="" mg/kg="" (doxorubicin="" 1)="" is="" administered="" in="" rats,="" 10="" daily="" intraperitoneal="" injections="" of="" 1="" mg/kg="" (doxorubicin="" 2),="" or="" in="" 5="" weekly="" intraperitoneal="" injections="" of="" 2="" mg/kg="" (doxorubicin="" 3).="" an="" 80%="" mortality="" rate="" is="" observed="" at="" day="" 28="" in="" doxorubicin="" 1,="" whereas="" doxorubicin="" 2="" and="" doxorubicin="" 3="" reached="" 80%="" mortality="" at="" days="" 107="" and="" 98,="" respectively.="" fractional="" shortening="" decreased="" by="" 30%="" at="" week="" 2="" in="" doxorubicin="" dox1,="" 55%="" at="" week="" 13="" in="" doxorubicin="" 2,="" and="" 42%="" at="" week="" 13="" in="" doxorubicin="">
- Fields：
- Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
- Specificity：
- Target:Topoisomerase. Fields: Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
- Source：
- Rabbit
- Dilution：
- WB 1:500-2000
- Concentration：
- 99%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- MolecularWeight(Da)：
- 579.98
- References：
- [1]. Nitiss JL, et al. Targeting DNA topoisomerase II in cancer chemotherapy.Nat Rev Cancer. 2009 May;9(5):338-50.[2]. Sadeghi-Aliabadi H, et al. Cytotoxic evaluation of doxorubicin in combination wi
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