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4000-520-616 / 18915418616
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0512-67156496
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商品描述
TORC1/CRTC1 (phospho-Ser151) rabbit pAb
- Catalog No.：YP1534
- Applications：WB
- Reactivity：Human
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- CRTC1 KIAA0616 MECT1 TORC1 WAMTP1
- Protein Name：
- TORC1/CRTC1 (Ser151)
- Human Gene Id：
- 23373
- Human Swiss Prot No：
- Q6UUV9
- Mouse Gene Id：
- 382056
- Mouse Swiss Prot No：
- Q68ED7
- Rat Gene Id：
- 684527
- Rat Swiss Prot No：
- Q157S1
- Immunogen：
- Synthesized phosho peptide around human TORC1 and CRTC1 (Ser151)
- Specificity：
- This antibody detects endogenous levels ofHuman TORC1 or CRTC1 (phospho-Ser151)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)
- Observed Band(KD)：
- 70
- Function：
- disease:A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.,function:Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 "Ser-133" phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator
- Subcellular Location：
- nucleus,nucleoplasm,cytoplasm,plasma membrane,dendrite,neuronal cell body,synapse,
- Expression：
- Brain,Carcinoma,Colon,Embryo,Eye,
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- June 19-2018
- FLOW CYTOMEYRT PROTOCOL
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
- July 13-2018
- Antibody-FAQs
