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商品描述
PLCγ1 (phospho-Ser1248)rabbit pAb
- Catalog No.：YP1445
- Applications：WB
- Reactivity：Human,Mouse
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- PLCG1 PLC1
- Protein Name：
- PLCγ1 (Ser1248)
- Human Gene Id：
- 5335
- Human Swiss Prot No：
- P19174
- Mouse Gene Id：
- 18803
- Mouse Swiss Prot No：
- Q62077
- Rat Gene Id：
- 25738
- Rat Swiss Prot No：
- P10686
- Immunogen：
- Synthesized phosho peptide around human PLCγ1 (Ser1248)
- Specificity：
- This antibody detects endogenous levels ofHuman Mouse PLCγ1 (phospho-Ser1248)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
- Observed Band(KD)：
- 150
- Background：
- phospholipase C gamma 1(PLCG1)Homo sapiensThe protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
- Function：
- catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,domain:The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1.,function:PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.,PTM:The receptor-mediated activation of PLC-gamma-1 and PLC-gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors.,PTM:Ubiquitinated by CBLB in activated T-cells.,similarity:Contains 1 C2 domain.,similarity:Contains 1 EF-hand domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,simil
- Subcellular Location：
- ruffle,intracellular,cytoplasm,cytosol,plasma membrane,cell-cell junction,COP9 signalosome,lamellipodium,cell projection,
- Expression：
- Brain,Epithelium,Testis,Vein,
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- Antibody-FAQs
