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0512-67156496
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商品描述
PLCγ2 (phospho-Tyr759) rabbit pAb
- Catalog No.：YP1446
- Applications：WB
- Reactivity：Human,Mouse
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- PLCG2
- Protein Name：
- PLCγ2 (Tyr759)
- Human Gene Id：
- 5336
- Human Swiss Prot No：
- P16885
- Mouse Gene Id：
- 234779
- Mouse Swiss Prot No：
- Q8CIH5
- Rat Gene Id：
- 29337
- Rat Swiss Prot No：
- P24135
- Immunogen：
- Synthesized phosho peptide around human PLCγ2 (Tyr759)
- Specificity：
- This antibody detects endogenous levels ofHuman Mouse PLCγ2 (phospho-Tyr759)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
- Observed Band(KD)：
- 148
- Background：
- phospholipase C gamma 2(PLCG2)Homo sapiensThe protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],
- Function：
- catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,
- Subcellular Location：
- intracellular,cytosol,plasma membrane,extracellular exosome,
- Expression：
- Lymph,Lymphoblast,Spleen,T-cell,
- June 19-2018
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- Antibody-FAQs
