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0512-67156496
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商品描述
Claudin 1 mouse mAb(PT0509)
- Catalog No.：YM4068
- Applications：IHC-p,WB
- Reactivity：Human
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- CLDN1 CLD1 SEMP1 UNQ481/PRO944
- Protein Name：
- Claudin 1
- Human Gene Id：
- 9076
- Human Swiss Prot No：
- O95832
- Immunogen：
- Synthesized peptide derived from human Claudin 1
- Specificity：
- This antibody detects endogenous levels of human Claudin 1
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Mouse/IgG2b, Kappa
- Dilution：
- IHC-p 1:100-300，WB 1:500-2000
- Purification：
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- Claudin-1 (Senescence-associated epithelial membrane protein)
- Background：
- claudin 1(CLDN1)Homo sapiensTight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008],
- Function：
- disease:Defects in CLDN1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH) [MIM:607626]; also called ichthyosis with leukocyte vacuoles alopecia and sclerosing cholangitis (ILVASC). NISCH is a rare autosomal recessive complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia, vulgar type ichthyosis, and sclerosing cholangitis.,function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). Acts as a co-receptor for HCV entry into hepatic cells.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL (By similarity). May interact with HCV E1 an
- Subcellular Location：
- integral component of plasma membrane,bicellular tight junction,integral component of membrane,apical plasma membrane,lateral plasma membrane,
- Expression：
- Trachea,Urinary bladder,
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- Antibody-FAQs
