Biological Activity
Irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).Technical Data
(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)
The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
- Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation.Sato et al.Cancer Res., 2007;67:9677
- Mode of inhibition of acid proteases by pepstatin.Marciniszyn et al.J.Biol.Chem., 1976;251:7088
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Citations for Pepstatin A
The citations listed below are publications that use Tocris products.Selected citations for Pepstatin A include:
3Citations: Showing 1 - 3
- Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation.Authors: Berg Et al.Cell Rep2019;27:2837
- Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.Authors: Guerroue Et al.Mol Cell2017;68:786
- WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma.Authors: Tsai Et al.J Neurosci2013;4:e792
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