The human CD1 genetic locus consists of five closely related genes (2). Three of the gene products (CD1a, CD1b and CD1c) have been officially clustered using antibodies and are expressed on cortical thymocytes, a subset of B cells, and on most professional antigen presenting cells (3). CD1 molecules have a specialized lipid antigen-presenting function (4,5) and it is unlikely that they present conventional peptide antigens. CD1 may also be involved in costimulation (6).

Isotype: Murine IgG1 kappa

Immunogen: Human T cell line Molt 4

Specificity: Antibody M241 is specific for the CD1c molecule of about 48 kd (1,2, 7).

References:

1. R.W. Knowles and W. F. Bodmer (1982) Eur J Immunol 12: 676-681.

2. Leukocyte Typing III (A.J. McMichael, et al, eds.) Oxford University Press, Oxford, (1987) p. 882.

3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 337-341.

4. E.M. Beckman, et al, (1994) Nature 372: 691-694.

5. R.S. Blumberg, et al, (1995) Immunol Rev 147: 5-29.

6. S.M. Behar, et al, (1995) J Exp Med 182: 2007-2018.

7. L H Martin, C Milstein, et al. (1987) PNAS 84: 9189-9193.

8. A -C R Beitnes, F L Jahnsen, et al (2011) Sandinavian J Immunol 74(2): 186-194. PMID: 21392045

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。