CD127 (IL-7Ra) is the specific receptor component for the cytokine Interleukin -7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors, and the majority of T cells. Its expression levels are decreased on T cells following activation. CD127 can dimerize with CD132(IL-2Rg) to form a high affinity IL-7 receptor (1). CD127 engagement is necessary for T cell development in humans (2).

Isotype: Murine IgG1 kappa

Immunogen: Recombinant human CD127

Specificity: Antibody ANC8F2 recognizes an extracellular epitope of human recombinant and native CD127 in FACS and Enzyme Immunoassay.

References:

1) Noguchi, M. et al., 1993, Science 262:1877.

2) Pribyl, J.A. and T.W. LeBien, 1996, Proc. Natl. Acad. Sci. 93:10348.

3) Goodwin RG, Friend D, Ziegler SF, et al. Cell. 1990;60:941.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。